Play with these census data.
In the past, to gather data like this (change in neighborhood population and demographics over 10 years) used to be so much work and take so long.
From 1990 to 2000, the Eastern District lost about 30% of its population. (In 2002 it took me days of work to figure that out.)
Between 2000 and 2010 the population of the Eastern decreased another 18%, bringing its population to roughly 37,750. (In 2011, it took me about an hour to figure that out.) With 39 homicides in 2010, the Eastern has a homicide rate of 103 per 100,000. Some things never change.
(And it seems worth pointing out that there were another 7 murders just south of the Eastern in the Southeast, north of Patterson Park and south of Monument Street.)